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Journal Article

Development of Broadband Cavity Ring-Down Spectroscopy for Biomedical Diagnostics of Liquid Analytes

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Kaminski,  C. F.
Max Planck Research Group, Max Planck Institute for the Science of Light, Max Planck Society;

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Citation

Kiwanuka, S.-.-S., Laurila, T. K., Frank, J. H., Esposito, A., von der Geest, K. B., Pancheri, L., et al. (2012). Development of Broadband Cavity Ring-Down Spectroscopy for Biomedical Diagnostics of Liquid Analytes. ANALYTICAL CHEMISTRY, 84(13), 5489-5493. doi:10.1021/ac301108q.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-68B7-7
Abstract
We present a spectrometer for sensitive absorption measurements in liquids across broad spectral bandwidths. The spectrometer combines the unique spectral properties of incoherent supercontinuum light sources with the advantages of cavity ring-down spectroscopy, which is a self-calibrating technique. A custom-built avalanche photodiode array is used for detection, permitting the simultaneous measurement of ring-down times for up to 64 different spectral components at nanosecond temporal resolution. The minimum detectable absorption coefficient was measured to be 3.2 x 10(-6) cm(-1) Hz at 527 nm. We show that the spectrometer is capable of recording spectral differences in trace levels of blood before and after hemolysis.