Segregation versus colocalization: orthogonally functionalized binary 
micropatterned substrates regulate the molecular distribution in focal adhesions

Guasch, Judit; Conings, Bert; Neubauer, Stefanie; Rechenmacher, Florian; Ende, Karen; Rolli, Claudio Gavino; Kappel, Christian; Schaufler, Viktoria; Micoulet, Alexandre; Kessler, Horst; Boyen, Hans-Gerd; Cavalcanti-Adam, Elisabetta Ada; Spatz, Joachim P.

doi:10.1002/adma.201500900

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Segregation versus colocalization: orthogonally functionalized binary micropatterned substrates regulate the molecular distribution in focal adhesions

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Guasch, Judit
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

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Micoulet, Alexandre
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

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Cavalcanti-Adam, Elisabetta Ada
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

/persons/resource/persons76135

Spatz, Joachim P.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

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Citation

Guasch, J., Conings, B., Neubauer, S., Rechenmacher, F., Ende, K., Rolli, C. G., et al. (2015). Segregation versus colocalization: orthogonally functionalized binary micropatterned substrates regulate the molecular distribution in focal adhesions. Advanced Materials, 27(25), 3737-3747. doi:10.1002/adma.201500900.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0028-2C9C-1

Abstract

Orthogonally functionalized binary micropatterned substrates are produced using a novel protocol. The use of adequate peptido-mimetics enables an unprecedented segregation of purified αvβ3 and α5β1 integrins in adjacent microislands and evidences the preference of U2OS cells to colocalize such receptors. Moreover, this tendency can be altered by varying the geometry and composition of the micropatterns.