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Journal Article

Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation

MPS-Authors
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Wei,  Qiang
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

/persons/resource/persons75953

Pohl,  Theresa M. L.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons76135

Spatz,  Joachim P.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

/persons/resource/persons75354

Cavalcanti-Adam,  Elisabetta Ada
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

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http://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-11-87.pdf
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https://dx.doi.org/10.3762/bjoc.11.87
(Any fulltext)

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Citation

Wei, Q., Pohl, T. M. L., Seckinger, A., Spatz, J. P., & Cavalcanti-Adam, E. A. (2015). Regulation of integrin and growth factor signaling in biomaterials for osteodifferentiation. Beilstein Journal of Organic Chemistry, 11, 773-783. doi:10.3762/bjoc.11.87.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0027-81D8-2
Abstract
Stem cells respond to the microenvironment (niche) they are located in. Under natural conditions, the extracellular matrix (ECM) is the essential component the in stem cell niche, in which both integrin ligands and growth factors are important regulators to directly or indirectly modulate the cell behavior. In this review, we summarize the current knowledge about the potential of integrin ligands and growth factors to induce osteogenic differentiation of stem cells, and discuss the signaling pathways that are initiated by both individual and cooperative parameters. The joint effect of integrin ligands and growth factors is highlighted as the multivalent interactions for bone therapy.