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Journal Article

Synthesis of binary nanopatterns on hydrogels for initiating cellular responses

MPS-Authors
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Guasch,  Judit
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

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Diemer,  Jennifer
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

/persons/resource/persons76135

Spatz,  Joachim P.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

External Resource

http://pubs.acs.org/doi/pdf/10.1021/acs.chemmater.5b04910
(Any fulltext)

http://pubs.acs.org/doi/suppl/10.1021/acs.chemmater.5b04910
(Supplementary material)

https://dx.doi.org/10.1021/acs.chemmater.5b04910
(Any fulltext)

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Citation

Guasch, J., Diemer, J., Riahinezhad, H., Neubauer, S., Kessler, H., & Spatz, J. P. (2016). Synthesis of binary nanopatterns on hydrogels for initiating cellular responses. Chemistry of Materials, 28(6), 1806-1815. doi:10.1021/acs.chemmater.5b04910.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002A-1BEF-C
Abstract
We describe the synthesis of binary nanostructures consisting of PEG hydrogels decorated with arrays of AuNPs and TiO2NPs, and their orthogonal functionalization with various peptides. These ligands are able to promote or elude cell adhesion through integrins, a family of transmembrane receptors that connect cells with the extracellular matrix (ECM) or other cells. The different cell adhesion behaviors observed depending on the peptides used, proved the functionality of such binary nanopatterns, which we expect to find applications not only in tissue engineering but also in smart cell culture systems and biosensors.