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Journal Article

T cell activation is determined by the number of presented antigens

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Deeg,  Janosch
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

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Spatz,  Joachim P.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

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Citation

Deeg, J., Axmann, M., Matic, J., Liapis, A., Depoil, D., Afrose, J., et al. (2013). T cell activation is determined by the number of presented antigens. Nano Letters, 13(11), 5090-5097. doi:10.1021/nl403266t.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0015-1025-B
Abstract
Antigen recognition is a key event during T cell activation. Here, we introduce nanopatterned antigen arrays that mimic the antigen presenting cell surface during T cell activation. The assessment of activation related events revealed the requirement of a minimal density of 90-140 stimulating major histocompatibility complex class II proteins (pMHC) molecules per μm(2). We demonstrate that these substrates induce T cell responses in a pMHC dose-dependent manner and that the number of presented pMHCs dominates over local pMHC density.