Hydrogel micropillars with integrin selective peptidomimetic functionalized 
nanopatterned tops: a new tool for the measurement of cell traction forces 
transmitted through αvβ3 - or α5β1 -Integrins

Rahmouni, Sabri; Lindner, Aaron; Rechenmacher, Florian; Neubauer, Stefanie; Sobahi, Tariq R. A.; Kessler, Horst; Cavalcanti-Adam, Elisabetta Ada; Spatz, Joachim P.

doi:10.1002/adma.201301338

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Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: a new tool for the measurement of cell traction forces transmitted through αvβ3 - or α5β1 -Integrins

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Rahmouni, Sabri
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

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Lindner, Aaron
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Cavalcanti-Adam, Elisabetta Ada
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

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Spatz, Joachim P.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

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Citation

Rahmouni, S., Lindner, A., Rechenmacher, F., Neubauer, S., Sobahi, T. R. A., Kessler, H., et al. (2013). Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: a new tool for the measurement of cell traction forces transmitted through αvβ3 - or α5β1 -Integrins. Advanced Materials, 25(41), 5869-5874. doi:10.1002/adma.201301338.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0014-B381-C

Abstract

Poly(ethylene glycol) micropillars with gold nanopatterns on top are functionalized with two integrin selective ligands. This platform is a powerful new tool to determine the specific contribution of traction forces involved in cell adhesion mediated by α5 β1- and αvβ3- integrins. Cells adherent via α5 β1-integrins have a tendency to exert higher maximum forces than cells adhering via αvβ3-integrins.