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Journal Article

Impact of local versus global ligand density on cellular adhesion

MPS-Authors
/persons/resource/persons75387

Deeg,  Janosch A.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

/persons/resource/persons75790

Louban,  Ilia
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons75235

Aydin,  Daniel
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons76100

Selhuber-Unkel,  Christine
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons76135

Spatz,  Joachim P.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

External Resource

http://pubs.acs.org/doi/pdf/10.1021/nl104079r
(Any fulltext)

https://dx.doi.org/10.1021/nl104079r
(Any fulltext)

http://pubs.acs.org/doi/suppl/10.1021/nl104079r
(Supplementary material)

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Citation

Deeg, J. A., Louban, I., Aydin, D., Selhuber-Unkel, C., Kessler, H., & Spatz, J. P. (2011). Impact of local versus global ligand density on cellular adhesion. Nano Letters, 11(4), 1469-1476. doi:10.1021/nl104079r.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-4D92-8
Abstract
α(v)β(3) integrin-mediated cell adhesion is crucially influenced by how far ligands are spaced apart. To evaluate the impact of local ligand density versus global ligand density of a given surface, we used synthetic micronanostructured cell environments with user-defined ligand spacing and patterns to investigate cellular adhesion. The development of stable focal adhesions, their number, and size as well as the cellular adhesion strength proved to be influenced by local more than global ligand density.