Deutsch
 
Benutzerhandbuch Datenschutzhinweis Impressum Kontakt
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Zeitschriftenartikel

Circular, nanostructured and biofunctionalized hydrogel microchannels for dynamic cell adhesion studies

MPG-Autoren
/persons/resource/persons75725

Kruss,  Sebastian
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

/persons/resource/persons76135

Spatz,  Joachim P.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte verfügbar
Ergänzendes Material (frei zugänglich)
Zitation

Kruss, S., Erpenbeck, L., Schön, M. P., & Spatz, J. P. (2012). Circular, nanostructured and biofunctionalized hydrogel microchannels for dynamic cell adhesion studies. Lab on a Chip, 12(18), 3285-3289. doi:10.1039/C2LC40611J.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0010-4BCB-9
Zusammenfassung
We report on a method to fabricate biofunctionalized polyethylene glycol hydrogel microchannels with adjustable circular cross-sections. The inner channel surfaces are decorated with Aunanoparticle arrays of tunable density. These Au-nanoparticles are functionalized with biomolecules whereas the hydrogel material provides an inert and biocompatible background. This technology provides control over flow conditions, channel curvature and biomolecule density on the channel surface. It can be applied for biophysical studies of cell-surface interactions mimicking, for example, leukocyte interactions with the endothelial lining in small vessels.