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Artificial niches: biomimetic materials for hematopoietic stem cell culture

MPG-Autoren
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Lee-Thedieck,  Cornelia
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Spatz,  Joachim P.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

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Zitation

Lee-Thedieck, C., & Spatz, J. P. (2012). Artificial niches: biomimetic materials for hematopoietic stem cell culture. Macromolecular Rapid Communications, 33(17), 1432-1438. doi:10.1002/marc.201200219.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0010-4BB4-C
Zusammenfassung
Hematopoietic stem cells (HSCs) are indispensable for the treatment of patients with hematological disorders such as leukemia. However, the amount of available transplantable HSCs is limited. Therefore, new approaches to multiply HSCs in the laboratory are needed. Promising biomimetic technologies for HSC expansion are currently developed. This feature article gives an insight into the significance of this approach and introduces the essential building blocks (cells, matrix, and scaffolds) of biomimetic materials. Some recent strategies are highlighted and the challenges and possible applications of such materials are discussed.