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Applying microdroplets as sensors for label-free detection of chemical reactions

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Hofmann,  Tobias W.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

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Janiesch,  Jan-Wilhelm
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

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Böhm,  Christian H. J.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

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Citation

Hofmann, T. W., Hänselmann, S., Janiesch, J.-W., Rademacher, A., & Böhm, C. H. J. (2012). Applying microdroplets as sensors for label-free detection of chemical reactions. Lab on a Chip, 12(5), 916-922. doi:10.1039/c2lc20971c.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-4B24-E
Abstract
Despite its tremendous high-throughput screening capabilities, widespread applications of droplet-based microfluidics are still limited by the poor availability of appropriate analytical assays. Here we report on a novel sensor method that exploits the osmosis-driven change in droplet size as a quantitative and label-free marker for reactions inside the droplets. We present an analysis of the underlying mechanism and apply the method for monitoring metabolic activity at a single-cell level.