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Biomimetic models of the actin cytoskeleton

MPS-Authors
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Curtis,  Jennifer E.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Roos,  Wouter
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Schulz,  Simon
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Uhrig,  Kai
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Spatz,  Joachim P.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

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Citation

Mohrdieck, C., Dalmas, F., Arzt, E., Tharmann, R., Claessens, M. M. A. E., Bausch, A. R., et al. (2007). Biomimetic models of the actin cytoskeleton. Small, 3(6), 1015-1022. doi:10.1002/smll.200600565.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-4373-9
Abstract
The cytoskeleton is a complex polymer network that plays an essential role in the functionality of eukaryotic cells. It endows cells with mechanical stability, adaptability, and motility. To identify and understand the mechanisms underlying this large variety of capabilities and to possibly transfer them to engineered networks makes it necessary to have in vitro and in silico model systems of the cytoskeleton. These models must be realistic representatives of the cellular network and at the same time be controllable and reproducible. Here, an approach to design complementary experimental and numerical model systems of the actin cytoskeleton is presented and some of their properties discussed.