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Journal Article

Small molecule detection by reflective interferometric fourier transform spectroscopy (RIFTS)


Pacholski,  Claudia
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

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Pacholski, C., Perelman, L. A., VanNieuwenhze, M. S., & Sailor, M. J. (2009). Small molecule detection by reflective interferometric fourier transform spectroscopy (RIFTS). Physica Status Solidi A, 206(6), 1318-1321. doi:10.1002/pssa.200881072.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-3E07-8
A new method for the compensation of matrix effects in biosensing experiments referred to as reflective interferometric Fourier transform spectroscopy (RIFTS) has been developed recently [1]. It employs a porous silicon sensor comprised of two porous silicon layers stacked one on top of the other. The structure has a complicated reflectivity spectrum that can be resolved by FFT analysis leading to three distinctive peaks which are assigned to the layers in the porous silicon structur. If the double layer is appropriately designed, the bottom layer can act as a reference channel. In this paper the specific sensing of small molecules using RIFTS is demonstrated for the first time. Ac-L-Lys-D-Ala-D-Ala has been immobilized to the sensor surface representing the capture probe and vancomycin was used as target analyte.