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The intron-enriched HERV-K(HML-10) family suppresses apoptosis, an indicator of malignant transformation

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Bröcker,  Felix
Chakkumal Anish, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Bröcker, F., Horton, R., Heinrich, J., Franz, A., Schweiger, M.-R., Lehrach, H., et al. (2016). The intron-enriched HERV-K(HML-10) family suppresses apoptosis, an indicator of malignant transformation. Mobile DNA, 7: 25. doi:10.1186/s13100-016-0081-9.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002C-25BA-F
Abstract
Human endogenous retroviruses (HERVs) constitute 8% of the human genome and contribute substantially to the transcriptome. HERVs have been shown to generate RNAs that modulate host gene expression. However, experimental evidence for an impact of these regulatory transcripts on the cellular phenotype has been lacking.