Glycan arrays and other tools produced by automated glycan assembly

Seeberger, Peter H.

doi:10.1016/j.pisc.2016.06.085

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Glycan arrays and other tools produced by automated glycan assembly

MPS-Authors

/persons/resource/persons121849

Seeberger, Peter H.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

Article.pdf
(Publisher version), 3MB

Supplementary Material (public)

There is no public supplementary material available

Citation

Seeberger, P. H. (2017). Glycan arrays and other tools produced by automated glycan assembly. Perspectives in Science, 11, 11-17. doi:10.1016/j.pisc.2016.06.085.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002C-2A35-2

Abstract

Carbohydrates are the dominant biopolymer on earth and play important roles ranging from building material for plants to function in many biological systems. Glycans remain poorly studied due to a lack of synthetic tools. The goal of my laboratory has been to develop a general method for the automated assembly of glycans. The general protocols we developed resulted in the commercialisation of the Glyconeer 2.1™ synthesizer as well as the building blocks and all reagents. Oligosaccharides as long as 50-mers are now accessible within days. Rapid access to defined oligosaccharides has been the foundation to many applications including synthetic tools such as glycan microarrays, glycan nanoparticles and anti-glycan antibodies. The platform technology is helping to address real-life problems by the creation of new vaccines and diagnostics. After addressing mainly mammalian glycobiology earlier, material science and plant biology are benefitting increasingly from synthetic glycans.