日本語
 
Help Privacy Policy ポリシー/免責事項
  詳細検索ブラウズ

アイテム詳細


公開

学術論文

Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.

MPS-Authors
/persons/resource/persons15891

Stühmer,  W.
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

/persons/resource/persons95089

Sakmann,  B.
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

External Resource
There are no locators available
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
フルテキスト (公開)

2376598.pdf
(出版社版), 2MB

付随資料 (公開)
There is no public supplementary material available
引用

Stühmer, W., Ruppersberg, J. P., Schröter, K. H., Sakmann, B., Stocker, M., Giese, K. P., Perschke, A., Baumann, A., & Pongs, O. (1989). Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO Journal, 8(11), 3235-3244.


引用: https://hdl.handle.net/11858/00-001M-0000-002C-289E-8
要旨
Cloning and sequencing of cDNAs isolated from a rat cortex cDNA library reveals that a gene family encodes several highly homologous K+ channel forming (RCK) proteins. Functional characterization of the channels expressed in Xenopus laevis oocytes following microinjection of in vitro transcribed RCK-specific RNAs shows that each of the RCK proteins forms K+ channels that differ greatly in both their functional and pharmacological properties. This suggests that the molecular basis for the diversity of voltage-gated K+ channels in mammalian brain is based, at least partly, on the expression of several RCK proteins by a family of genes and their assembly to homooligomeric K+ channels with different functional properties.