Molecular basis of functional diversity of voltage-gated potassium channels in 
mammalian brain.

Stühmer, W.; Ruppersberg, J. P.; Schröter, K. H.; Sakmann, B.; Stocker, M.; Giese, K. P.; Perschke, A.; Baumann, A.; Pongs, O.

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Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.

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Stühmer, W.
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Sakmann, B.
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Stühmer, W., Ruppersberg, J. P., Schröter, K. H., Sakmann, B., Stocker, M., Giese, K. P., et al. (1989). Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. EMBO Journal, 8(11), 3235-3244.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002C-289E-8

Abstract

Cloning and sequencing of cDNAs isolated from a rat cortex cDNA library reveals that a gene family encodes several highly homologous K+ channel forming (RCK) proteins. Functional characterization of the channels expressed in Xenopus laevis oocytes following microinjection of in vitro transcribed RCK-specific RNAs shows that each of the RCK proteins forms K+ channels that differ greatly in both their functional and pharmacological properties. This suggests that the molecular basis for the diversity of voltage-gated K+ channels in mammalian brain is based, at least partly, on the expression of several RCK proteins by a family of genes and their assembly to homooligomeric K+ channels with different functional properties.