Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress.

Volk, Naama; Pape, Julius C.; Engel, Mareen; Zannas, Anthony S.; Cattane, Nadia; Cattaneo, Annamaria; Binder, Elisabeth B.; Chen, Alon

doi:10.1016/j.celrep.2016.10.038

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学術論文

Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress.

MPS-Authors

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Volk, Naama
external;
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons141924

Pape, Julius C.
external;
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons118976

Engel, Mareen
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons160236

Zannas, Anthony S.
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80272

Binder, Elisabeth B.
external;
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons129892

Chen, Alon
external;
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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1-s2.0-S2211124716314437-main.pdf
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引用

Volk, N., Pape, J. C., Engel, M., Zannas, A. S., Cattane, N., Cattaneo, A., Binder, E. B., & Chen, A. (2016). Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress. Cell reports, 17(7), 1882-1891. doi:10.1016/j.celrep.2016.10.038.

引用: https://hdl.handle.net/11858/00-001M-0000-002C-413F-3

要旨

MicroRNAs are important regulators of gene expression and associated with stress-related psychiatric disorders. Here, we report that exposing mice tochronic stress led to a specific increase in microRNA-15a levels in the amygdala-Ago2 complex and a concomitant reduction in the levels of its predicted target, FKBP51, which is implicated in stress-related psychiatric disorders. Reciprocally, mice expressing reduced levels of amygdalar microRNA-15a following exposure to chronic stress exhibited increased anxiety-like behaviors. In humans, pharmacological activation of the glucocorticoid receptor, as well as exposure to childhood trauma, was associated with increased microRNA-15a levels in peripheral blood. Taken together, our results support an important role for microRNA-15ain stress adaptation and the pathogenesis of stress-related psychopathologies.