Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue

Duteil, Delphine; Tosic, Milica; Lausecker, Franziska; Nenseth, Hatice Z.; Müller, Judith M.; Urban, Sylvia; Willmann, Dominica; Petroll, Kerstin; Messaddeq, Nadia; Arrigoni, Laura; Manke, Thomas; Kornfeld, Jan-Wilhelm; Brüning, Jens C.; Zagoriy, Vyacheslav; Meret, Michael; Dengjel, Jörn; Kanouni, Toufike; Schüle, Roland

doi:10.1016/j.celrep.2016.09.053

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Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue

MPS-Authors

Arrigoni, Laura
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Manke, Thomas
Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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https://www.sciencedirect.com/science/article/pii/S221112471631292X?via%3Dihub
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引用

Duteil, D., Tosic, M., Lausecker, F., Nenseth, H. Z., Müller, J. M., Urban, S., Willmann, D., Petroll, K., Messaddeq, N., Arrigoni, L., Manke, T., Kornfeld, J.-W., Brüning, J. C., Zagoriy, V., Meret, M., Dengjel, J., Kanouni, T., & Schüle, R. (2016). Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue. Cell Reports, 17, 1008-1021. doi:10.1016/j.celrep.2016.09.053.

引用: https://hdl.handle.net/11858/00-001M-0000-002C-AF3F-8

要旨

Previous work indicated that lysine-specific demethylase 1 (Lsd1) can positively regulate the oxidative and thermogenic capacities of white and beige adipocytes. Here we investigate the role of Lsd1 in brown adipose tissue (BAT) and find that BAT-selective Lsd1 ablation induces a shift from oxidative to glycolytic metabolism. This shift is associated with downregulation of BAT-specific and upregulation of white adipose tissue (WAT)-selective gene expression. This results in the accumulation of di- and triacylglycerides and culminates in a profound whitening of BAT in aged Lsd1-deficient mice. Further studies show that Lsd1 maintains BAT properties via a dual role. It activates BAT-selective gene expression in concert with the transcription factor Nrf1 and represses WAT-selective genes through recruitment of the CoREST complex. In conclusion, our data uncover Lsd1 as a key regulator of gene expression and metabolic function in BAT.