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Journal Article

Cell Division: Flipping the Mitotic Switches

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Zachariae,  Wolfgang
Zachariae, Wolfgang / Chromosome Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Zachariae, W., & Tyson, J. J. (2016). Cell Division: Flipping the Mitotic Switches. Current Biology, 26(24), R1272-R1274. doi:10.1016/j.cub.2016.11.007.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002C-57A0-3
Abstract
Alternation between DNA replication in the mother cell (S phase) and equal partitioning of the replicated chromosomes to the daughter cells (M phase) during eukaryotic cell division is governed by switches that flip protein kinases on and off. New work reveals that the M-phase promoting kinase is opposed by a phosphatase that also participates in a bistable switching mechanism.