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Intracellular magnesium blocks sodium outward currents in a voltage- and dose-dependent manner.

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Pusch,  M.
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Stühmer,  W.
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Citation

Pusch, M., Conti, F., & Stühmer, W. (1989). Intracellular magnesium blocks sodium outward currents in a voltage- and dose-dependent manner. Biophysical Journal, 55(6), 1267-1271. doi:10.1016/S0006-3495(89)82922-4.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002C-4760-5
Abstract
Tail currents through Na+ channels have been measured in inside-out patches from Xenopus laevis oocytes injected with cDNA-derived mRNA coding for the rat brain type II Na+ channel. It is shown that intracellular Mg2+ blocks outward currents in a voltage- and dose-dependent manner with a half blocking concentration between 3 and 4 mM at 0 mV and a voltage dependence of e-fold per 49 mV.