English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Dyslexia risk gene relates to representation of sound in the auditory brainstem

MPS-Authors
/persons/resource/persons85245

Neef,  Nicole
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons130230

Liebig,  Johanna
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons86916

Schaadt,  Gesa
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department of Psychology, Humboldt University Berlin, Germany;

/persons/resource/persons19674

Grigutsch,  Maren
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19687

Gunter,  Thomas C.
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons20002

Skeide,  Michael A.
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons73219

Kraft,  Indra
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19570

Brauer,  Jens
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19643

Friederici,  Angela D.
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

Locator
There are no locators available
Fulltext (public)

Neef_2018.pdf
(Publisher version), 2MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Neef, N., Müller, B., Liebig, J., Schaadt, G., Grigutsch, M., Gunter, T. C., et al. (2017). Dyslexia risk gene relates to representation of sound in the auditory brainstem. Developmental Cognitive Neuroscience, 24, 63-71. doi:10.1016/j.dcn.2017.01.008.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002C-47A3-F
Abstract
Dyslexia is a reading disorder with strong associations with KIAA0319 and DCDC2. Both genes play a functional role in spike time precision of neurons. Strikingly, poor readers show an imprecise encoding of fast transients of speech in the auditory brainstem. Whether dyslexia risk genes are related to the quality of sound encoding in the auditory brainstem remains to be investigated. Here, we quantified the response consistency of speech-evoked brainstem responses to the acoustically presented syllable [da] in 159 genotyped, literate and preliterate children. When controlling for age, sex, familial risk and intelligence, partial correlation analyses associated a higher dyslexia risk loading with KIAA0319 with noisier responses. In contrast, a higher risk loading with DCDC2 was associated with a trend towards more stable responses. These results suggest that unstable representation of sound, and thus, reduced neural discrimination ability of stop consonants, occurred in genotypes carrying a higher amount of KIAA0319 risk alleles. Current data provide the first evidence that the dyslexia-associated gene KIAA0319 can alter brainstem responses and impair phoneme processing in the auditory brainstem. This brain-gene relationship provides insight into the complex relationships between phenotype and genotype thereby improving the understanding of the dyslexia-inherent complex multifactorial condition.