A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar 
Affinity that Prevents Efficient Inhibitor Release by Arl2

Martín-Gago, Pablo; Fansa, Eyad K.; Klein, Christian; Murarka, Sandip; Janning, Petra; Schürmann, Marc; Metz, Malte; Ismail, Shehab; Schultz-Fademrecht, Carsten; Baumann, Matthias; Bastiaens, Philippe I. H.; Wittinghofer, Alfred; Waldmann, Herbert

doi:10.1002/anie.201610957

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A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2

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Martín-Gago, Pablo
Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons134252

Fansa, Eyad K.
Sonstige Wissenschaftliche Organisationseinheiten, Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons137009

Klein, Christian
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons118542

Murarka, Sandip
Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons98701

Janning, Petra
Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons192314

Schürmann, Marc
Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons202224

Metz, Malte
Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons118803

Ismail, Shehab
Sonstige Wissenschaftliche Organisationseinheiten, Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons98677

Bastiaens, Philippe I. H.
Abt. II: Systemische Zellbiologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons98738

Wittinghofer, Alfred
Sonstige Wissenschaftliche Organisationseinheiten, Max Planck Institute of Molecular Physiology, Max Planck Society;

/persons/resource/persons98735

Waldmann, Herbert
Abt. IV: Chemische Biologie, Max Planck Institute of Molecular Physiology, Max Planck Society;

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Citation

Martín-Gago, P., Fansa, E. K., Klein, C., Murarka, S., Janning, P., Schürmann, M., et al. (2017). A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2. Angewandte Chemie International Edition, 56(9), 2423-2428. doi:10.1002/anie.201610957.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002C-4B3D-6

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