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Journal Article

Influence of epidermal growth factor on long-term potentiation in the hippocampal slice.

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Terlau,  H.
Abteilung Neurobiologie, MPI for biophysical chemistry, Max Planck Society;

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Seifert,  W.
Abteilung Neurobiologie, MPI for biophysical chemistry, Max Planck Society;

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2385076.pdf
(Publisher version), 378KB

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Citation

Terlau, H., & Seifert, W. (1989). Influence of epidermal growth factor on long-term potentiation in the hippocampal slice. Brain Research, 484(1-2), 352-356. doi:10.1016/0006-8993(89)90380-6.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002C-4BE1-0
Abstract
Rat hippocampal slices were perfused with epidermal growth factor (EGF) at a concentration of 10−8 M. EGF is a well known mitogen which exhibits neurotrophic action on neurons of the CNS. During extra- and intracellular recordings in the pyramidal cell body layer of the CA1-region no influence of EGF on evoked potentials was seen if single-pulse or paired-pulse stimulation was used. Furthermore EGF has no influence on the resting membrane potential of the cells investigated. However after tetanic stimulation a significant increase in the magnitude of long-term potentiation was observed. Therefore it is concluded, that EGF might be involved in modulation of neuronal plasticity.