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Exploiting noncovalent interactions in an imine-based covalent organic framework for quercetin delivery

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Vishwakarma,  Medhavi
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

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Spatz,  Joachim P.
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;
Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany;

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Citation

Vyas, V. S., Vishwakarma, M., Moudrakovski, I., Haase, F., Savasci, G., Ochsenfeld, C., et al. (2016). Exploiting noncovalent interactions in an imine-based covalent organic framework for quercetin delivery. Advanced Materials Interfaces, 28(39), 8749-8754. doi:10.1002/adma.201603006.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002C-45F4-9
Abstract
Covalent organic frameworks (COFs) are a new class of nanoporous polymeric vector showing promise as drug-delivery vehicles with high loading capacity and biocompatibility. The interaction between the carrier and the cargo is specifically tailored on a molecular level by H-bonding. Cell-proliferation studies indicate higher efficacy of the drug in cancer cells by nanocarrier delivery mediated by the COF.