日本語
 
User Manual Privacy Policy ポリシー/免責事項 連絡先
  詳細検索ブラウズ

アイテム詳細


公開

学術論文

Biomolecule Arrays Using Functional Combinatorial Particle Patterning on Microchips

MPS-Authors
There are no MPG-Authors available
URL
There are no locators available
フルテキスト (公開)
公開されているフルテキストはありません
付随資料 (公開)
There is no public supplementary material available
引用

Löffler, F., Schirwitz, C., Wagner, J., Koenig, K., Maerkle, F., Torralba, G., Hausmann, M., Bischoff, F. R., Nesterov-Mueller, A., & Breitling, F. (2012). Biomolecule Arrays Using Functional Combinatorial Particle Patterning on Microchips. Advanced Functional Materials, 22(12), 2503-2508. doi:10.1002/adfm.201103103.


引用: http://hdl.handle.net/11858/00-001M-0000-002C-5114-2
要旨
Biofunctionalization of surfaces in a microarray format has revolutionized biological assay applications. Here, a microarray system based on a microelectronic chip is presented that allows for a versatile combinatorial in situ molecule synthesis with very high density. Successfully demonstrating an application for peptide array synthesis, the method offers a compact approach, high combinatorial freedom, and, due to the intrinsic alignment, high and reproducible precision. Patterning the chip surface with different microparticle types which imbed different monomers, several thousand different molecule types can be simultaneously elongated layer-by-layer by coupling the particle imbedded monomers to the molecules growing on the chip surface. This technique has the potential for a wide application in combinatorial chemistry, as long as the desired monomeric building blocks are compatible with the chemical process.