Multiple memory mechanisms? The long and the short of it

Bannerman, David M.; Sprengel, Rolf

doi:10.1038/emboj.2010.90

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Multiple memory mechanisms? The long and the short of it

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Sprengel, Rolf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Bannerman, D. M., & Sprengel, R. (2010). Multiple memory mechanisms? The long and the short of it. The EMBO Journal, 29(11), 1790-1791. doi:10.1038/emboj.2010.90.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002C-5125-B

Abstract

Synaptic plasticity is known to be intrinsically linked to cytoskeletal remodelling. In a new study published in this issue of The EMBO Journal, Rust et al have therefore generated and analysed a forebrain-specific mouse knockout of the actin-severing factor n-cofilin. Intriguingly, these mice exhibit a particular form of learning impairment-intact working memory but impaired spatial reference memory, correlating with a deficit in long-lasting long-term potentiation (LTP).