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Journal Article

Engineering fatty acid synthases for directed polyketide production.

MPS-Authors
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Buelens,  F. P.
Department of Theoretical and Computational Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Grubmüller,  H.
Department of Theoretical and Computational Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Fulltext (public)

2400704.pdf
(Publisher version), 516KB

Supplementary Material (public)

2400704_Suppl_1.pdf
(Supplementary material), 9MB

2400704_Suppl_2.tar
(Supplementary material), 11MB

Citation

Gajewski, J., Buelens, F. P., Serdjukow, S., Janßen, M., Cortina, N., Grubmüller, H., et al. (2017). Engineering fatty acid synthases for directed polyketide production. Nature Chemical Biology, 13(4), 363-365. doi:10.1038/nchembio.2314.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002C-8359-6
Abstract
In this study, we engineered fatty acid synthases (FAS) for the biosynthesis of short-chain fatty acids and polyketides, guided by a combined in vitro and in silico approach. Along with exploring the synthetic capability of FAS, we aim to build a foundation for efficient protein engineering, with the specific goal of harnessing evolutionarily related megadalton-scale polyketide synthases (PKS) for the tailored production of bioactive natural compounds.