Engineering fatty acid synthases for directed polyketide production.

Gajewski, J.; Buelens, F. P.; Serdjukow, S.; Janßen, M.; Cortina, N.; Grubmüller, H.; Grininger, M.

doi:10.1038/nchembio.2314

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Engineering fatty acid synthases for directed polyketide production.

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Buelens, F. P.
Department of Theoretical and Computational Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Grubmüller, H.
Department of Theoretical and Computational Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Zitation

Gajewski, J., Buelens, F. P., Serdjukow, S., Janßen, M., Cortina, N., Grubmüller, H., et al. (2017). Engineering fatty acid synthases for directed polyketide production. Nature Chemical Biology, 13(4), 363-365. doi:10.1038/nchembio.2314.

Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002C-8359-6

Zusammenfassung

In this study, we engineered fatty acid synthases (FAS) for the biosynthesis of short-chain fatty acids and polyketides, guided by a combined in vitro and in silico approach. Along with exploring the synthetic capability of FAS, we aim to build a foundation for efficient protein engineering, with the specific goal of harnessing evolutionarily related megadalton-scale polyketide synthases (PKS) for the tailored production of bioactive natural compounds.