Some Subtle Lessons from the Calyx of Held Synapse

Neher, E.

doi:10.1016/j.bpj.2016.12.017

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Some Subtle Lessons from the Calyx of Held Synapse

MPS-Authors

/persons/resource/persons15570

Neher, E.
Emeritus Group of Membrane Biophysics, MPI for Biophysical Chemistry, Max Planck Society;

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

2403698.pdf
(出版社版), 687KB

付随資料 (公開)

There is no public supplementary material available

引用

Neher, E. (2017). Some Subtle Lessons from the Calyx of Held Synapse. Biophysical Journal, 112(2), 215-223. doi:10.1016/j.bpj.2016.12.017.

引用: https://hdl.handle.net/11858/00-001M-0000-002C-8E24-8

要旨

The calyx of Held is a giant nerve terminal that forms a glutamatergic synapse in the auditory pathway. Due to its large size, it offers a number of advantages for biophysical studies, including voltage-clamp of both pre- and postsynaptic compartments and the loading with indicator dyes and caged compounds. Three aspects of recent findings on the calyx are reviewed here, each of which seems to have only subtle consequences for nerve-evoked excitatory postsynaptic currents: vesicle heterogeneity, refractoriness of release sites, and superpriming. Together, they determine short-term plasticity features that are superficially similar to those expected for a simple vesicle pool model. However, detailed consideration of these aspects may be required for the correct mechanistic interpretation of data from synapses with normal and perturbed function, as well as for modeling the dynamics of short-term plasticity.