Effect of ether lipids on mouse granulocyte-macrophage progenitor cells.

Vehmeyer, K.; Kim, D. J.; Nagel, G.; Eibl, H. J.; Unger, C.

doi:10.1007/BF00254107

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Effect of ether lipids on mouse granulocyte-macrophage progenitor cells.

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Eibl, H. J.
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Citation

Vehmeyer, K., Kim, D. J., Nagel, G., Eibl, H. J., & Unger, C. (1989). Effect of ether lipids on mouse granulocyte-macrophage progenitor cells. Cancer Chemotherapy and Pharmacology, 24(1), 58-60. doi:10.1007/BF00254107.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002C-9154-7

Abstract

In this study we determined the potential bone marrow toxicity of the ether lipid derivatives 1-0-octadecyl-2-0-methyl-rac-glycero-3-phosphocholine (OcMe-G-3-PC), 1-0-hexadecyl-propanediol-2-phosphocholine (He-Pr-2-PC), and hexadecylphosphocholine (He-PC). OcMe-G-3-PC inhibited the proliferation of mouse granulocytemacrophage progenitor cells (GM-CFCs) at a dose of 1 μg/ml, whereas He-Pr-2-PC and He-PC started to inhibit the growth of hemopoietic precursors at 5 μg/ml. In contrast to this finding, NMRI mice given 10 mg/kg i.v. daily for 4 weeks and 20 or 30 mg/kg for 5 days showed no bone marrow toxicity. We conclude that the dose-dependent toxic effects observed in vitro are within the physiological tolerance in vivo.