Soluble ephrin a1 is necessary for the growth of HeLa and SK-BR3 cells

Alford, Spencer; Watson-Hurthig, Adam; Scott, Nadia; Carette, Amanda; Lorimer, Heather; Bazowski, Jessa; Howard, Perry L.

doi:10.1186/1475-2867-10-41

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Soluble ephrin a1 is necessary for the growth of HeLa and SK-BR3 cells

MPS-Authors

There are no MPG-Authors in the publication available

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

Alford_Soluble_CancerCellInt_2010.pdf
(Publisher version), 5MB

Supplementary Material (public)

There is no public supplementary material available

Citation

Alford, S., Watson-Hurthig, A., Scott, N., Carette, A., Lorimer, H., Bazowski, J., et al. (2010). Soluble ephrin a1 is necessary for the growth of HeLa and SK-BR3 cells. Cancer Cell International, 10: 41. doi:10.1186/1475-2867-10-41.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002C-9E4D-4

Abstract

Ephrin A1 (EFNA1) is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. In malignancy, the precise role of EFNA1 and its preferred receptor, EPHA2, is controversial. Several studies have found that EFNA1 may suppress EPHA2-mediated oncogenesis, or enhance it, depending on cell type and context. However, little is known about the conditions that influence whether EFNA1 promotes or suppresses tumorigenicity. EFNA1 exists in a soluble form as well as a glycophosphatidylinositol (GPI) membrane attached form. We investigated whether the contradictory roles of EFNA1 in malignancy might in part be related to the existence of both soluble and membrane attached forms of EFNA1 and potential differences in the manner in which they interact with EPHA2.