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学術論文

The stereochemistry of fatty acid hydroxylation by cytochrome P450BM3

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Cryle,  Max
Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society;

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引用

Cryle, M., Matovic, N. J., & De Voss, J. J. (2007). The stereochemistry of fatty acid hydroxylation by cytochrome P450BM3. Tetrahedron Letters, 48(1), 133-136. doi:10.1016/j.tetlet.2006.10.136.


引用: http://hdl.handle.net/11858/00-001M-0000-002C-A795-A
要旨
The stereochemical preference for the cytochrome P450BM3-catalysed hydroxylation of tetradecanoic and pentadecanoic acids has been determined via comparison with authentic non-racemic standards utilising enantioselective HPLC. The sub-terminal hydroxylation of these fatty acids by P450BM3 is highly selective for the formation of the R-alcohols. This is the same enantioselectivity as is seen for hexadecanoic acid oxidation but contrasts with a previous report of S-hydroxylation of pentadecanoic acid by P450BM3.