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Self-organizing networks of molecular machines in allosterically regulated enzymic reactions

MPG-Autoren
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Stange,  Pedro
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Hess,  Benno
Emeritus Group Prof. Dr. B. Hess, Max Planck Institute for Medical Research, Max Planck Society;

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Zitation

Mikhailov, A. S., Stange, P., Zanette, D. H., & Hess, B. (1999). Self-organizing networks of molecular machines in allosterically regulated enzymic reactions. In D. Reguera, J. Vilar, & J. Rubí (Eds.), Statistical Mechanics of Biocomplexity (pp. 72-92). Berlin: Springer. doi:10.1007/BFb0105009.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-002C-ACA3-F
Zusammenfassung
The diffusive mixing and delivery times of regulatory molecules in micrometer and submicrometer reaction volumes can be shorter than the characteristic times of conformational transformations in single enzyme molecules. Under these conditions, mutual synchronization of individual molecular turnover cycles takes place when strong allosteric activation by reaction products is present. Using a simple stochastic automaton model to describe the cycles of single molecules, we analyze properties of this synchronization transition and discuss the importance of such microscopic self-organization phenomena for functioning of biological cells.