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Journal Article

Cerebellar LTD and pattern recognition by Purkinje cells

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Mittmann,  Wolfgang
Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society;

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Häusser,  Michael
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Steuber, V., Mittmann, W., Hoebeek, F. E., Silver, R. A., De Zeeuw, C. I., Häusser, M., et al. (2007). Cerebellar LTD and pattern recognition by Purkinje cells. Neuron, 54(1), 121-136. doi:10.1016/j.neuron.2007.03.015.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002C-AD88-5
Abstract
Many theories of cerebellar function assume that long-term depression (LTD) of parallel fiber (PF) synapses enables Purkinje cells to learn to recognize PF activity patterns. We have studied the LTD-based recognition of PF patterns in a biophysically realistic Purkinje-cell model. With simple-spike firing as observed in vivo, the presentation of a pattern resulted in a burst of spikes followed by a pause. Surprisingly, the best criterion to distinguish learned patterns was the duration of this pause. Moreover, our simulations predicted that learned patterns elicited shorter pauses, thus increasing Purkinje-cell output. We tested this prediction in Purkinje-cell recordings both in vitro and in vivo. In vitro, we found a shortening of pauses when decreasing the number of active PFs or after inducing LTD. In vivo, we observed longer pauses in LTD-deficient mice. Our results suggest a novel form of neural coding in the cerebellar cortex.