How tRNAs dictate nuclear codon reassignments: Only a few can capture 
non-cognate codons.

Kollmar, M.; Mühlhausen, S.

doi:10.1080/15476286.2017.1279785

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

How tRNAs dictate nuclear codon reassignments: Only a few can capture non-cognate codons.

MPS-Authors

/persons/resource/persons15357

Kollmar, M.
Research Group of Systems Biology of Motor Proteins, MPI for biophysical chemistry, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Kollmar, M., & Mühlhausen, S. (2017). How tRNAs dictate nuclear codon reassignments: Only a few can capture non-cognate codons. RNA Biology, 14(3), 293-299. doi:10.1080/15476286.2017.1279785.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002C-E630-E

Abstract

mRNA decoding by tRNAs and tRNA charging by aminoacyl-tRNA synthetases are biochemically separated processes that nevertheless in general involve the same nucleotides. The combination of charging and decoding determines the genetic code. Codon reassignment happens when a differently charged tRNA replaces a former cognate tRNA. The recent discovery of the polyphyly of the yeast CUG sense codon reassignment challenged previous mechanistic considerations and led to the proposal of the so-called tRNA loss driven codon reassignment hypothesis. Accordingly, codon capture is caused by loss of a tRNA or by mutations in the translation termination factor, subsequent reduction of the codon frequency through reduced translation fidelity and final appearance of a new cognate tRNA. Critical for codon capture are sequence and structure of the new tRNA, which must be compatible with recognition regions of aminoacyl-tRNA synthetases. The proposed hypothesis applies to all reported nuclear and organellar codon reassignments.