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Journal Article

A morphometric analysis of synaptic vesicle distributions.


Fox,  G.
Research Group of Electron Microscopy, MPI for biophysical chemistry, Max Planck Society;

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Fox, G. (1988). A morphometric analysis of synaptic vesicle distributions. Brain Research, 475(1), 103-117. doi:10.1016/0006-8993(88)90203-X.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-2B87-E
Synaptic vesicle populations have been morphometrically analyzed for size and density. Populations composed of a single size class of vesicles are represented by normal (Gaussian) or positive (log-normal)skew histograms. Populations with multiple size classes generate negative (left) skew distributions. Fixatives containing aldehydes differentially affect these distribution patterns but vesicles are able to withstand tonic effects over a wide range. Reader bias' contribute the most error in the data-collecting process. But despite this, the sizing of vesicle populations can be accomplished with great accuracy. Vesicle density computations, on the other hand, vary over a wide range and are of less value for comparative purposes.