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A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine.

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Chowdhury,  K.
Department of Molecular Cell Biology, MPI for Biophysical Chemistry, Max Planck Society;

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Dressler,  G.R.
Department of Molecular Cell Biology, MPI for biophysical chemistry, Max Planck Society;

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Balling,  R.
Department of Molecular Cell Biology, MPI for biophysical chemistry, Max Planck Society;

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Gruß,  P.
Department of Molecular Cell Biology, MPI for biophysical chemistry, Max Planck Society;

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Citation

Duprey, P., Chowdhury, K., Dressler, G., Balling, R., Simon, D., Guenet, J. L., et al. (1988). A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine. Genes and Development, 2(12A), 1647-1654. doi:10.1101/gad.2.12a.1647.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002D-2BF5-3
Abstract
A mouse gene, Cdx-1, was isolated from an embryonic cDNA library using a Drosophila caudal gene probe. The deduced amino acid sequence of Cdx-1 contains conserved sequence domains along the entire gene, as well as a highly conserved caudal-type homeo box. A structural comparison suggests a common ancestral origin of mouse Cdx-1 and Drosophila caudal. The expression of Cdx-1 during embryogenesis was analyzed by Northern blotting and in situ hybridization. Cdx-1-specific transcripts are localized in the epithelial lining of the intestines beginning at 14 days' gestation. The expression of Cdx-1 in the intestine continues into adulthood, but cannot be detected in any other tissues. The Cdx-1 gene is the first homeo-box-containing gene expressed in cells derived from the embryonic endoderm.