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Journal Article

Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress

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Ramot,  Assaf
external;
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Nahum,  Tali
external;
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Chen,  Alon
external;
Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society;

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Citation

Ramot, A., Jiang, Z., Tian, J.-B., Nahum, T., Kuperman, Y., Justice, N., et al. (2017). Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress. NATURE NEUROSCIENCE, 20(3), 385-388. doi:10.1038/nn.4491.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-A7BB-4
Abstract
The hypothalamic-pituitary-adrenal axis is a pivotal component of an organism's response to stressful challenges, and dysfunction of this neuroendocrine axis is associated with a variety of physiological and psychological pathologies. We found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic-pituitary adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.