Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Synthesis and Neurotrophic Activity Studies of Illicium Sesquiterpene Natural Product Analogues


Sippel,  Claudia
Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Richers, J., Poethig, A., Herdtweck, E., Sippel, C., Hausch, F., & Tiefenbacher, K. (2017). Synthesis and Neurotrophic Activity Studies of Illicium Sesquiterpene Natural Product Analogues. CHEMISTRY - A EUROPEAN JOURNAL, 23(13), 3178-3183. doi:10.1002/chem.201605362.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-A627-7
Neurotrophic natural products hold potential as privileged structures for the development of therapeutic agents against neurodegeneration. However, only a few studies have been conducted to investigate a common pharmacophoric motif and structure-activity relationships (SARs). Here, an investigation of structurally more simple analogues of neurotrophic sesquiterpenes of the illicium family is presented. A concise synthetic route enables preparation of the carbon framework of (+/-)-MerrilactoneA and (+/-)-Anislactone A/B on a gram scale. This has allowed access to a series of structural analogues by modification of the core structure, including variation of oxidation levels and alteration of functional groups. In total, 15 derivatives of the natural products have been synthesized and tested for their neurite outgrowth activities. Our studies indicate that the promising biological activity can be retained by structurally simpler natural product analogues, which are accessible by a straightforward synthetic route.