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Automated glycan assembly of branched β-(1,3)-glucans to identify antibody epitopes

MPS-Authors
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Weishaupt,  M. W.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Hahm,  H. S.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Geissner,  A.
Chakkumal Anish, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Seeberger,  Peter H.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Weishaupt, M. W., Hahm, H. S., Geissner, A., & Seeberger, P. H. (2017). Automated glycan assembly of branched β-(1,3)-glucans to identify antibody epitopes. Chemical Communications, 53(25), 3591-3594. doi:10.1039/C7CC00520B.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002D-53C3-9
Abstract
β-(1,3)-Glucans exhibit immunomodulatory and anti-tumor effects. Since the isolation of pure β-(1,3)-glucan oligosaccharides from natural sources is complicated, especially when certain branching patterns are desired, chemical synthesis is frequently the only means of accessing these molecules. We report the iterative automated glycan assembly (AGA) of conjugation-ready linear and branched β-(1,3)-glucan oligosaccharides.