Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Rapid short-term reorganization in the language network


Hartwigsen,  Gesa
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

(Publisher version), 2MB

Supplementary Material (public)
There is no public supplementary material available

Hartwigsen, G., Bzdok, D., Klein, M., Wawrzyniak, M., Stockert, A., Wrede, K., et al. (2017). Rapid short-term reorganization in the language network. eLife, 6: e25964. doi:10.7554/eLife.25964.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-522F-1
The adaptive potential of the language network to compensate for lesions remains elusive. We show that perturbation of a semantic region in the healthy brain induced suppression of activity in a large semantic network and upregulation of neighbouring phonological areas. After perturbation, the disrupted area increased its inhibitory influence on another semantic key node. The inhibitory influence predicted the individual delay in response speed, indicating that inhibition at remote nodes is functionally relevant. Individual disruption predicted the upregulation of semantic activity in phonological regions. In contrast, perturbation over a phonological region suppressed activity in the network and disrupted behaviour without inducing upregulation. The beneficial contribution of a neighbouring network might thus depend on the level of functional disruption and may be interpreted to reflect a differential compensatory potential of distinct language networks. These results might reveal generic mechanisms of plasticity in cognitive networks and inform models of language reorganization.