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Implications of the thyroid hormone on neuronal development with special emphasis on the calmodulin-kinase IV pathway.

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Krebs,  J.
Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society;

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Fulltext (public)

2450985.pdf
(Publisher version), 748KB

Supplementary Material (public)

2450985_Suppl.pdf
(Supplementary material), 2MB

Citation

Krebs, J. (2017). Implications of the thyroid hormone on neuronal development with special emphasis on the calmodulin-kinase IV pathway. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1864(6), 877-882. doi:10.1016/j.bbamcr.2016.12.004.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002D-5A3E-C
Abstract
Thyroid hormones influence brain development through regulation of gene expression. This is especially true for Ca2 +-dependent regulation since a major pathway is controlled by the Ca2 +/calmodulin-dependent protein kinase IV (CaMKIV) which in turn is induced by the thyroid hormone T3. In addition, CaMKIV is involved in regulation of alternative splicing of a number of protein isoforms, among them PMCA1a, the neuronal specific isoform of the plasma membrane calcium pump. On the other hand, hypothyroidism or CaMKIV deficiency can have a severe influence on brain development. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech.