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Journal Article

The effect of diethylether upon the function of the vesicles of sarcoplasmic reticulum

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Fiehn,  W.
Max Planck Institute for Medical Research, Max Planck Society;

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Hasselbach,  Wilhelm
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Fiehn, W., & Hasselbach, W. (1969). The effect of diethylether upon the function of the vesicles of sarcoplasmic reticulum. European Journal of Biochemistry, 9(4), 574-578. doi:10.1111/j.1432-1033.1969.tb00647.x.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002D-78A4-3
Abstract
1The calcium permeability of the sarcoplasmic vesicles is greatly increased when vesicular suspensions are extracted with ether. 2A 7–8% v/v aqueous ether solution abolishes the calcium concentrating ability of the vesicles completely. The calcium remaining in the solution permanently activates the calcium magnesium dependent ATPase. 3In parallel to the change of the permeability of the vesicular membranes membranal lipids are removed by the ether treatment. Concentrations of ether which produce a maximal permeability increase only extract cholesterol esters. Higher concentrations of ether which inhibit the transport ATPase remove neutral lipids and phospholipids. The basic ATPase is not affected.