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Journal Article

Hemmung der Phalloidinvergiftung in vitro durch 4,7-Phenanthrolin


Jahn,  Werner
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Jahn, W. (1972). Hemmung der Phalloidinvergiftung in vitro durch 4,7-Phenanthrolin. Naunyn-Schmiedebergs Archives of Pharmacology, 272(2), 182-188. doi:10.1007/BF00508768.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-83A0-9
1. In the presence of 4,7-phenanthroline (30 mg/80 ml), phalloidin has no effect on the potassium content or the weight of the isolated rat liver. 2. Application of 4,7-phenanthroline to the poisoned liver, which has lost most of its potassium, causes a re-uptake of 83±9% of the released potassium. 3. When the perfusion medium was exchanged after the phenanthroline induced potassium re-uptake, the greater part of this amount of potassium is released again. A second application of 4,7-phenanthroline causes a complete re-uptake of the potassium. 4. Dipyridamol and hexobendin show similar effects on the phalloidin poisoned liver as 4,7-phenanthroline.