Vitamin D effects on osteoblastic differentiation of mesenchymal stem cells 
from dental tissues

Posa, Francesca; Di Benedetto, Adriana; Colaianni, Graziana; Cavalcanti-Adam, Elisabetta Ada; Brunetti, Giacomina; Porro, Chiara; Trotta, Teresa; Grano, Maria; Mori, Giorgio

doi:10.1155/2016/9150819

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Vitamin D effects on osteoblastic differentiation of mesenchymal stem cells from dental tissues

MPS-Authors

/persons/resource/persons75354

Cavalcanti-Adam, Elisabetta Ada
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

External Resource

http://downloads.hindawi.com/journals/sci/2016/9150819.pdf
(全文テキスト（全般）)

http://dx.doi.org/10.1155/2016/9150819
(全文テキスト（全般）)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Posa, F., Di Benedetto, A., Colaianni, G., Cavalcanti-Adam, E. A., Brunetti, G., Porro, C., Trotta, T., Grano, M., & Mori, G. (2016). Vitamin D effects on osteoblastic differentiation of mesenchymal stem cells from dental tissues. Stem Cells International, 2016:, pp. 1-9. doi:10.1155/2016/9150819.

引用: https://hdl.handle.net/11858/00-001M-0000-002D-9391-C

要旨

1α,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the active metabolite of vitamin D (Vit D), increases intestinal absorption of calcium and phosphate, maintaining a correct balance of bone remodeling. Vit D has an anabolic effect on the skeletal system and is key in promoting osteoblastic differentiation of human Mesenchymal Stem Cells (hMSCs) from bone marrow. MSCs can be also isolated from the immature form of the tooth, the dental bud: Dental Bud Stem Cells (DBSCs) are adult stem cells that can effectively undergo osteoblastic differentiation. In this work we investigated the effect of Vit D on DBSCs differentiation into osteoblasts. Our data demonstrate that DBSCs, cultured in an opportune osteogenic medium, differentiate into osteoblast-like cells; Vit D treatment stimulates their osteoblastic features, increasing the expression of typical markers of osteoblastogenesis like RUNX2 and Collagen I (Coll I) and, in a more important way, determining a higher production of mineralized matrix nodules.