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Similarity between the effect of experimental congestion of the isolated perfused rat liver and the action of cytochalasin B

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Jahn,  Werner
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Jahn, W. (1973). Similarity between the effect of experimental congestion of the isolated perfused rat liver and the action of cytochalasin B. Naunyn-Schmiedebergs Archives of Pharmacology, 278(4), 431-434. doi:10.1007/BF00501485.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002D-9E33-8
Abstract
Livers of rats were perfused with dextran solutions, containing no red cells. Changes in the dextran concentration due to water shifts between the intra- and extracellular space of the liver were recorded continuously by polarimetric measurement. Cytochalasin B causes an uptake of potassium and water, followed by a release of water and a spontaneously reversible release of potassium, while the liver weight increases. From these effects an uptake of dextran, probably by an endocytotic process, is concluded.