Deutsch
 
Benutzerhandbuch Datenschutzhinweis Impressum Kontakt
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Zeitschriftenartikel

Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules

MPG-Autoren
/persons/resource/persons39214

del Toro,  Daniel
Department: Molecules-Signaling-Development / Klein, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons137088

Ruff,  Tobias
Department: Molecules-Signaling-Development / Klein, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons207153

Cederfjäll,  Erik
Department: Molecules-Signaling-Development / Klein, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons78696

Seyit-Bremer,  Gönül
Department: Molecules-Signaling-Development / Klein, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons38927

Klein,  Rüdiger
Department: Molecules-Signaling-Development / Klein, MPI of Neurobiology, Max Planck Society;

Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

del Toro, D., Ruff, T., Cederfjäll, E., Villalb, A., Seyit-Bremer, G., Borrell, V., et al. (2017). Regulation of Cerebral Cortex Folding by Controlling Neuronal Migration via FLRT Adhesion Molecules. Cell, 169(4), 621-635. doi:10.1016/j.cell.2017.04.012.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-002D-A5A2-C
Zusammenfassung
The folding of the mammalian cerebral cortex into sulci and gyri is thought to be favored by the amplification of basal progenitor cells and their tangential migration. Here, we provide a molecular mechanism for the role of migration in this process by showing that changes in intercellular adhesion of migrating cortical neurons result in cortical folding. Mice with deletions of FLRT1 and FLRT3 adhesion molecules develop macroscopic sulci with preserved layered organization and radial glial morphology. Cortex folding in these mutants does not require progenitor cell amplification but is dependent on changes in neuron migration. Analyses and simulations suggest that sulcus formation in the absence of FLRT1/3 results from reduced intercellular adhesion, increased neuron migration, and clustering in the cortical plate. Notably, FLRT1/3 expression is low in the human cortex and in future sulcus areas of ferrets, suggesting that intercellular adhesion is a key regulator of cortical folding across species.