Item

ITEM ACTIONS

This item is discarded!Release HistoryDetailsSummary

Discarded

Journal Article

Formation and maintenance of functional spines in the absence of presynaptic glutamate release

MPS-Authors

/persons/resource/persons200352

Kwon, Hyung-Bae
MPI of Neurobiology, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Sigler, A., Oh, W. C., Imig, C., Altas, B., Kawabe, H., Cooper, B. H., et al. (2017). Formation and maintenance of functional spines in the absence of presynaptic glutamate release. Neuron, 94(2), 304-311.e4. doi:10.1016/j.neuron.2017.03.029.

Abstract

Dendritic spines are the major transmitter reception compartments of glutamatergic synapses in most principal neurons of the mammalian brain and play a key role in the function of nerve cell circuits. The formation of functional spine synapses is thought to be critically dependent on presynaptic glutamatergic signaling. By analyzing CA1 pyramidal neurons in mutant hippocampal slice cultures that are essentially devoid of presynaptic transmitter release, we demonstrate that the formation and maintenance of dendrites and functional spines are independent of synaptic glutamate release.