Radiosynthesis of SPECT tracers via a copper mediated 123I iodination of 
(hetero)aryl boron reagents

Wilson, Thomas C.; McSweeney, Greg; Preshlock, Sean; Verhoog, Stefan; Tredwell, Mathew; Caily, Thomas; Gouverneur, Veronique

doi:10.1039/C6CC07417K

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Radiosynthesis of SPECT tracers via a copper mediated ¹²³I iodination of (hetero)aryl boron reagents

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Tredwell, Mathew
Chemistry Research Laboratory, Department of Chemistry;
Research Group Tredwell, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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引用

Wilson, T. C., McSweeney, G., Preshlock, S., Verhoog, S., Tredwell, M., Caily, T., & Gouverneur, V. (2016). Radiosynthesis of SPECT tracers via a copper mediated ¹²³I iodination of (hetero)aryl boron reagents. Chemical Communications, 13277-13280. doi:10.1039/C6CC07417K.

引用: https://hdl.handle.net/11858/00-001M-0000-002D-AEE4-A

要旨

A general method for the copper mediated nucleophilic ¹²³I-iodination of (hetero)aryl boronic esters and acids has been developed. The broad substrate scope of this radiosynthetic approach allows access to [¹²³I]DPA-713, [¹²³I]IMPY, [¹²³I]MIBG and [¹²³I]IPEB that are four commonly used SPECT radiotracers. Our results infer that aryl boronic reagents can now be employed as common precursors for both fluorine-18 and iodine-123 radiolabelling.