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Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications

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Tredwell,  Mathew
Research Group Tredwell, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Preshlock, S., Calderwood, S., Verhoog, S., Tredwell, M., Huiban, M., Hienzsch, A., et al. (2016). Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications. Chemical Communications, 52, 8361-8364. doi:10.1039/C6CC03295H.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002D-B122-5
Abstract
[18F]FMTEB, [18F]FPEB, [18F]flumazenil, [18F]DAA1106, [18F]MFBG, [18F]FDOPA, [18F]FMT and [18F]FDA are prepared from the corresponding arylboronic esters and [18F]KF/K222 in the presence of Cu(OTf)2py4. The method was successfully applied using three radiosynthetic platforms, and up to 26 GBq of non-carrier added starting activity of 18F-fluoride.