The central dogma decentralized: New perspectives on RNA function and local 
translation in neurons

Holt, C.; Schuman, E.

doi:10.1016/j.neuron.2013.10.036

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Review Article

The central dogma decentralized: New perspectives on RNA function and local translation in neurons

MPS-Authors

/persons/resource/persons208206

Schuman, E.
Synaptic Plasticity Department, Max Planck Institute for Brain Research, Max Planck Society;

External Resource

https://pubmed.ncbi.nlm.nih.gov/24183017/
(Any fulltext)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Holt, C., & Schuman, E. (2013). The central dogma decentralized: New perspectives on RNA function and local translation in neurons. Neuron, 80(3), 648-657.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002E-1CB2-1

Abstract

The elaborate morphology of neurons together with the information processing that occurs in remote dendritic and axonal compartments makes the use of decentralized cell biological machines necessary. Recent years have witnessed a revolution in our understanding of signaling in neuronal compartments and the manifold functions of a variety of RNA molecules that regulate protein translation and other cellular functions. Here we discuss the view that mRNA localization and RNA-regulated and localized translation underlie many fundamental neuronal processes and highlight key issues for future experiments.